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The Functions of Alternative Splicing

22-23 juin 2020
Jussieu Campus, Sorbonne Université. 4 Place Jussieu. - Paris, Île-de-France (France)

http://fas.sciencesconf.org

Alternative splicing (AS) greatly contributes to functional diversity in multicellular eukaryotes. It augments and enriches the protein repertoire by generating multiple transcript isoforms from the same gene. In Human, AS affects almost all multi-exonic genes and its deregulation leads to diseases like cancer. From an evolutionary perspective, about 25% of the AS events common to human and mouse are also conserved in vertebrates. This supports an essential role of AS in expanding the protein repertoire through evolution. In the last decade, in-depth surveys of the splicing complexity across species have become possible, thanks to the advent of high-throughput sequencing technologies like RNA-Seq, or Mass Spectrometry. However, most studies are mainly observational and only provide insights about AS regulation. Hence, there is a need to move towards more mechanistic interpretations of the role of AS in the cell and disease. This issue can be addressed through different angles, at the cross-talk between sequence and structure. The goal of this meeting will be to present a panorama of the current research about the function of alternative splicing. It will gather people from different backgrounds working on the subject of alternative splicing: wet-lab biologists, computational biologists from genomics to structural bioinformatics.
Discipline scientifique : Bio-informatique - Biologie moléculaire - Biologie structurale - Génomique, Transcriptomique et Protéomique - Réseaux moléculaires - Biologie cellulaire - Biologie du développement - Biologie de la reproduction - Bio-Informatique, Biologie Systémique

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